Role of Pneumococcal Vaccine in HIV Infected Population.

1Senior Consultant, Institute of Infectious Diseases, Apollo Hospitals, Chennai; Adjunct Professor, Tamil Nadu Dr. MGR Medical University; Adjunct Associate Professor, Apollo Hospitals Educational and Research Foundation. S v e r e a n d r e c u r r e n t pneumococcal disease is more common with HIV infect ion. 13 Adults infected with human immunodeficiency virus (HIV) are at high risk for Streptococcus pneumoniae infections as a result of humoral immune dysfunction. The reported incidence rates of invasive pneumococcal disease in HIV-infected adults range from 197 to 5700 per 100,000 personyears, which are 6to 324-fold higher than rates for uninfected adults.1 Given the increased risk for pneumococcal disease, vaccination with the pneumococcal conjugate vacc ines reduce vacc ine type invasive pneumococcal disease and radiographically-confirmed p n e u m o n i a i n c h i l d r e n w i t h HIV 4. In addition, the 7-valent pneumococcal conjugate vaccine was effective against vaccine-type invasive pneumococcal disease in a randomized controlled trial of HIV-infected adults with a recent history of pneumococcal disease.5